|
|
| Nomenclature |
|
Symbol:
|
Trp53tm2.1Tyj
|
|
Name:
|
transformation related protein 53;
targeted mutation 2.1, Tyler Jacks
|
|
MGI ID: |
MGI:3039264 |
|
Synonyms: |
p53R172H, p53 R172H, TrpR172H |
|
Gene:
|
Trp53
Location:
Chr11:69580359-69591873 bp, + strand
Genetic Position: Chr11,
42.83 cM, cytoband B2-C
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:95316
|
|
Parent Cell Line:
| J1 (ES Cell) |
|
Strain of Origin:
|
129S4/SvJae
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutation: | |
Nucleotide substitutions |
| |
|
Mutation details: The loxP flanked stop cassette was removed from Trp53tm2Tyj via cre-mediated recombination, leaving an R172H missense mutation in exon 5. Quantitative real-time PCR confirmed that the point mutation allele is expressed at a level comparable to wild-type. (J:95316)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:95316
Olive KP et al.,
"Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome."
Cell 2004 Dec 17;119(6):847-60
|
|
All: |
8 reference(s)
|
|
Analysis Tools
