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| Nomenclature |
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Symbol:
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Tg(CMV-Rpgr)1Tili
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Name:
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transgene insertion 1, Tiansen Li
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MGI ID: |
MGI:3038604 |
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Transgene:
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Tg(CMV-Rpgr)1Tili
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A mouse Rpgr ORF15 variant cDNA was inserted between the cytomegalovirus (CMV) enhancer promoter and the polyadenylation sequence of bovine growth hormone. The cDNA used in this construct is shortened by 654 base pairs in the purine-rich region of the ORF15 exon when compared to the published sequence of the 129/Sv mouse strain. This construct was used to generate transgenic mice by pronuclear injection. Transgene protein accumulates to a much lower level than the endogenous protein and migrated at a size smaller than the native protein. (J:87299)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:87299
Hong DH et al.,
"Dominant, gain-of-function mutant produced by truncation of RPGR."
Invest Ophthalmol Vis Sci 2004 Jan;45(1):36-41
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All: |
1 reference(s)
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Analysis Tools
