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| Nomenclature |
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Symbol:
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Ightm5Cgn
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Name:
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immunoglobulin heavy chain complex;
targeted mutation 5, University of Cologne
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MGI ID: |
MGI:3037892 |
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Synonyms: |
LMP2AflSTOP |
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Gene:
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Igh
Location:
unknown
Genetic Position: Chr12,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88472
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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BALB/c
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: To conditionally express the Epstein-Barr virus protein, LMP2A, from either the endogenous weak DQ52 promoter or an inserted strong Igh-V 186.2 promoter, sequence encoding LMP2A was inserted downstream of a loxP-flanked stop cassette. Floxed Igh-V 186.2 promoter sequence was included in the targeting vector between the DQ52 promoter and the floxed stop cassette (which contained frt-flanked neo followed by stop codons). Germline excision of the floxed Igh-V promoter and the stop cassette led to the production of Ightm5.1Cgn. (J:88472)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Igh Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:88472
Casola S et al.,
"B cell receptor signal strength determines B cell fate."
Nat Immunol 2004 Mar;5(3):317-27
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All: |
1 reference(s)
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Analysis Tools
