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| Nomenclature |
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Symbol:
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Ddb2tm1Linn
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Name:
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damage specific DNA binding protein 2;
targeted mutation 1, Stuart Linn
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MGI ID: |
MGI:3036308 |
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Synonyms: |
Ddb2- |
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Gene:
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Ddb2
Location:
Chr2:91211572-91236982 bp, - strand
Genetic Position: Chr2,
50.56 cM, cytoband E1
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Tumorigenesis analysis and Hisptopathological images
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88125
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 4 through 7 were replaced with a neomycin selection cassette via homologous recombination. The absence of expression in homozygous mutant MEFs was confirmed by RT-PCR and Western blot analysis. (J:88125)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ddb2 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:88125
Itoh T et al.,
"DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen."
Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2052-7
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All: |
2 reference(s)
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Analysis Tools
