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| Nomenclature |
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Symbol:
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Junbtm3Wag
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Name:
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Jun-B oncogene;
targeted mutation 3, Erwin F Wagner
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MGI ID: |
MGI:3036209 |
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Synonyms: |
junBdelta, junBf |
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Gene:
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Junb
Location:
Chr8:84976909-84978748 bp, - strand
Genetic Position: Chr8,
41.41 cM, cytoband C2-D1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88126
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed and frt-flanked selection cassette containing both a neomycin resistance gene and a thymidine kinase gene was inserted in the 5' untranslated region. An additional loxP site was inserted 161 bp downstream of the translation stop codon. The neomycin and thymidine kinase genes were subsequently deleted from properly targeted ES cells by transient transfection with a flp recombinase expressing vector leaving the coding sequence flanked by loxP sites. Northern blot and Western blot analysis confirmed the absence of both transcripts and protein product. (J:88126)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Junb Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:88126
Kenner L et al.,
"Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects."
J Cell Biol 2004 Feb 16;164(4):613-23
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All: |
17 reference(s)
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Analysis Tools
