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| Nomenclature |
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Symbol:
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Tg(PML-RARA)556Kog
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Name:
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transgene insertion 556, Scott Kogan
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MGI ID: |
MGI:3033300 |
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Synonyms: |
hMRP8-PML-RARalpha, MRP8-PMLRARalpha, PML/RARalpha |
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Transgene:
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Tg(PML-RARA)556Kog
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene is a human PMLRARalpha cDNA cloned into the hMRP8 expression cassette (MRP8 is a synonym for S100A8, which is S100 calcium binding protein A8 (calgranulin A)). (J:39327)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Line #556 has the highest level of transgene expression of the nine lines created for this study. All mice carrying this transgene on an FVB/N genetic background developed skin papillomas.
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| References |
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Original: |
J:39327
Brown D et al.,
"A PMLRARalpha transgene initiates murine acute promyelocytic leukemia."
Proc Natl Acad Sci U S A 1997 Mar 18;94(6):2551-6
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All: |
12 reference(s)
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Analysis Tools
