|
|
| Nomenclature |
|
Symbol:
|
GckRgsc552
|
|
Name:
|
glucokinase;
RIKEN Genomic Sciences Center (GSC), 552
|
|
MGI ID: |
MGI:3033230 |
|
Synonyms: |
early onset diabetes, 9 RIKEN GSC, Gck9Rgsc, GckF419L, M-552, Rgcs552 |
|
Gene:
|
Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
|
|
Mutation
origin |
|
Strain of Origin:
|
C57BL/6J
|
|
Mutation
description |
|
Allele
Type: | |
Chemically induced (ENU) |
|
Mutation: | |
Single point mutation |
| |
|
Mutation details: C to A transversion in exon 10 results in a missense mutation and substitution of leucine for phenylalanine at amino acid 419. (J:88919, J:137483)
|
|
Inheritance: | |
Dominant |
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:88919
Inoue M et al.,
"A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program."
Hum Mol Genet 2004 Jun 1;13(11):1147-57
|
|
All: |
2 reference(s)
|
|
Analysis Tools
