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| Nomenclature |
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Symbol:
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GckRgsc702
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Name:
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glucokinase;
RIKEN Genomic Sciences Center (GSC), 702
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MGI ID: |
MGI:3033227 |
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Synonyms: |
early onset diabetes, 6 RIKEN GSC, Gck6Rgsc, GckR345Stop, M-702, Rgsc702 |
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Gene:
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Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: C to T transition in exon 9 results in a nonsense mutation and changes an Arginine into a stop at amino acid 345. Real time PCR and immunoblotting found decreased liver Gck mRNA, protein expression and Gck activity were reduced. (J:88919, J:137483)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:88919
Inoue M et al.,
"A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program."
Hum Mol Genet 2004 Jun 1;13(11):1147-57
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All: |
2 reference(s)
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Analysis Tools
