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| Nomenclature |
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Symbol:
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GckRgsc272
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Name:
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glucokinase;
early onset diabetes, 2 RIKEN GSC
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MGI ID: |
MGI:3033223 |
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Synonyms: |
early onset diabetes, 2 RIKEN GSC, Gck2Rgsc, GckM224R, M-272, Rgsc272 |
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Gene:
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Gck
Location:
Chr11:5900820-5950081 bp, - strand
Genetic Position: Chr11,
3.88 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: T to G transversion in exon 6 results in a missense mutation and substitution of arginine for methionine at amino acid 224. Real time PCR on liver samples detected no change in Gck mRNA expression however liver protein levels and Gck activity are reduced(J:88919, J:137483)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:88919
Inoue M et al.,
"A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program."
Hum Mol Genet 2004 Jun 1;13(11):1147-57
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All: |
2 reference(s)
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Analysis Tools
