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| Nomenclature |
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Symbol:
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Tg(aP2-SREBF1c)9884Reh
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Name:
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transgene insertion 9884, Robert E Hammer
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MGI ID: |
MGI:3028848 |
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Synonyms: |
aP2-SREBP-1c436 |
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Transgene:
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Tg(aP2-SREBF1c)9884Reh
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Sequence encoding residues 1 through 436 of human nuclear sterol regulatory element binding protein-1c (SREBF1c) was adjoined to 5.4 kb of the mouse adipose-specific enhancer/promoter of aP2. SREBF1c sequence encoding the membrane-attachment domain was not included in the construct, permitting the expressed componen to enter the nucleus without a requirement for proteolysis. (J:50770)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
This line was generated from founder number 988-4.
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| References |
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Original: |
J:50770
Shimomura I et al.,
"Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy."
Genes Dev 1998 Oct 15;12(20):3182-94
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All: |
10 reference(s)
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Analysis Tools
