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| Nomenclature |
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Symbol:
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Ercc4tm1Fwa
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Name:
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excision repair cross-complementing rodent repair deficiency, complementation group 4;
targeted mutation 1, Frederick W Alt
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MGI ID: |
MGI:3028660 |
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Synonyms: |
XPFm |
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Gene:
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Ercc4
Location:
Chr16:13109684-13150617 bp, + strand
Genetic Position: Chr16,
8.93 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:87684
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The endogenous exon 8 was replaced with a mutant version containing a nonsense mutation at codon 445. A single loxP site remained in intron 7 after the excision of a floxed neo cassette. Though the mutation was expected to generate a truncated transcript, message was undetected by RT-PCR analysis of homozygous mutant MEFs. (J:87684)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ercc4 Mutation:
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51 strains or lines available |
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| References |
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Original: |
J:87684
Tian M et al.,
"Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF."
Mol Cell Biol 2004 Feb;24(3):1200-5
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All: |
6 reference(s)
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Analysis Tools
