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| Nomenclature |
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Symbol:
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Mre11atm1Jpt
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Name:
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meiotic recombination 11 homolog A (S. cerevisiae);
targeted mutation 1, John H J Petrini
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MGI ID: |
MGI:3027036 |
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Synonyms: |
Mre11ATLD1 |
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Gene:
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Mre11a
Location:
Chr9:14784654-14837123 bp, + strand
Genetic Position: Chr9,
4.33 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:87088
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Single point mutation |
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Mutation details: An A-to-T transversion point mutation was engineered at nucleotide 1894 of the coding sequence to recapitulate a nonsense mutation identified in human patients (codon 633). This mutation results in the truncation of 75 amino acids. (J:87088)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mre11a Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:87088
Theunissen JW et al.,
"Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice."
Mol Cell 2003 Dec;12(6):1511-23
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All: |
10 reference(s)
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Analysis Tools
