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| Nomenclature |
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Symbol:
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TxnipHyplip1
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Name:
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thioredoxin interacting protein;
hyperlipidemia 1
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MGI ID: |
MGI:2687368 |
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Synonyms: |
Txnip-, txniphcb |
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Gene:
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Txnip
Location:
Chr3:96557957-96561883 bp, + strand
Genetic Position: Chr3,
41.93 cM, cytoband F2.2
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Mutation
origin |
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Strain of Origin:
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HcB19/Dem
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: A T-to-A transversion mutation at position 337 in the 1,456-bp cDNA results in a tyrosine (TAT) to a stop codon (TAA) alteration at amino acid 97 in the encoded protein. This mutation was absent in the C3H parental strain and all other strains observed. A decreased level of mutant transcript was expressed from this allele. (J:75395)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Txnip Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:47109
Castellani LW et al.,
"Mapping a gene for combined hyperlipidaemia in a mutant mouse strain."
Nat Genet 1998 Apr;18(4):374-7
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All: |
10 reference(s)
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Analysis Tools
