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| Nomenclature |
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Symbol:
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Ptprotm1Wig
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Name:
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protein tyrosine phosphatase, receptor type, O;
targeted mutation 1, Roger C Wiggins
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MGI ID: |
MGI:2687220 |
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Synonyms: |
GLEPP1 knockout, Ptpro- |
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Gene:
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Ptpro
Location:
Chr6:137252299-137464629 bp, + strand
Genetic Position: Chr6,
66.75 cM
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Glomeruli podocyte abnormalities in Ptprotm1Wig/Ptprotm1Wig mice
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:65903
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot and immunofluorescence analyses of homozygous mutant mice, however a polypeptide larger than that produced by the endogenous locus was detected at levels less than 1.2% those of wild-type. (J:65903)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ptpro Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:65903
Wharram BL et al.,
"Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate."
J Clin Invest 2000 Nov;106(10):1281-90
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All: |
5 reference(s)
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Analysis Tools
