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| Nomenclature |
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Symbol:
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Cdkn2atm4Rdp
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Name:
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cyclin-dependent kinase inhibitor 2A;
targeted mutation 4, Ronald DePinho
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MGI ID: |
MGI:2687203 |
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Synonyms: |
Ink4a/ARFF2-3, Ink4a/Arflox, Ink4a/Arf Lox, Ink4a-p19ARF- |
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Gene:
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Cdkn2a
Location:
Chr4:89274473-89294653 bp, - strand
Genetic Position: Chr4,
42.15 cM, cytoband C3-C6
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:87196
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exons 2 and 3 were left flanked by single loxP sites after an frt-flanked neo cassette was excised from intron 3 via FLP-mediated recombination. (J:87196)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cdkn2a Mutation:
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22 strains or lines available |
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| References |
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Original: |
J:87196
Aguirre AJ et al.,
"Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma."
Genes Dev 2003 Dec 15;17(24):3112-26
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All: |
29 reference(s)
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Analysis Tools
