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| Nomenclature |
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Symbol:
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Pomctm2Ute
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Name:
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pro-opiomelanocortin-alpha;
targeted mutation 2, Ute Hochgeschwender
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MGI ID: |
MGI:2687084 |
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Gene:
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Pomc
Location:
Chr12:3954951-3960618 bp, + strand
Genetic Position: Chr12,
1.99 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:57503
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded all but the first 44 residues of the preprotein (all but 18 residues of the mature protein). (J:57503)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:57503
Yaswen L et al.,
"Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin [see comments]"
Nat Med 1999 Sep;5(9):1066-70
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All: |
9 reference(s)
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Analysis Tools
