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| Nomenclature |
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Symbol:
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Mpltm1Fjs
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Name:
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myeloproliferative leukemia virus oncogene;
targeted mutation 1, Frederic J de Sauvage
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MGI ID: |
MGI:2686901 |
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Synonyms: |
c-Mpl-, c-Mpl delta60 |
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Gene:
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Mpl
Location:
Chr4:118442415-118457513 bp, - strand
Genetic Position: Chr4,
54.61 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:87416
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Parent Cell Line:
| GS1 (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 11 and 12, which includes the sequence for the intracellular region, were replaced with a complex sequence including a cDNA fragment encoding only the first half of the cytoplasmic signaling domain, an SV40 polyadenylation site, and a floxed PGK-neomycin cassette. Western blot analysis demonstrated that the resulting protein product had been modified to a size consistent with a 60 amino acid deletion. (J:87416)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mpl Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:87416
Luoh SM et al.,
"Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo."
Mol Cell Biol 2000 Jan;20(2):507-15
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All: |
7 reference(s)
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Analysis Tools
