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| Nomenclature |
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Symbol:
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Tg(Rho)1Wbae
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Name:
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transgene insertion 1, Wolfgang Baehr
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MGI ID: |
MGI:2686794 |
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Synonyms: |
VPP |
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Transgene:
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Tg(Rho)1Wbae
Location:
unknown
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Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice
Show the 1 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x SJL
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgenic construct contained a 15 kb genomic fragment encompassing the mouse rhodopsin gene. 3 substitution mutations were engineered in exon 1 (V20G, P23H, and P27L). 6 kb of upstream sequence and 3 kb of downstream sequence were included in the construct. Northern blot analysis showed that both the inserted mutant rhodopsin transcript and the wild-type transcript are present in transgenic mice, indicating that the site of integration is not at the endogenous rhodopsin locus. (J:12791)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:12791
Naash MI et al.,
"Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene."
Proc Natl Acad Sci U S A 1993 Jun 15;90(12):5499-503
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All: |
12 reference(s)
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Analysis Tools
