Emx1tm1(cre)Krj
Targeted Allele Detail
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| Nomenclature |
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Symbol:
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Emx1tm1(cre)Krj
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Name:
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empty spiracles homeobox 1;
targeted mutation 1, Kevin R Jones
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MGI ID: |
MGI:2684610 |
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Synonyms: |
emx1-cre, Emx1IREScre, Emx1-IRES-Cre |
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Gene:
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Emx1
Location:
Chr6:85187438-85204462 bp, + strand
Genetic Position: Chr6,
37.21 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:78098
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: An IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain. (J:78098)
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Recombinase activity
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Activity in:
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alimentary system,
branchial arches,
hemolymphoid system,
integumental system,
limbs,
mesenchyme,
nervous system,
renal & urinary system,
sensory organs
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Not detected in:
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adipose tissue,
cardiovascular system,
embryo-other,
endocrine system,
extraembryonic component,
liver & biliary system,
muscle,
postnatal-other,
reproductive system,
respiratory system,
skeletal system,
tail
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Driver:
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Emx1
Summary of all recombinase alleles
driven by Emx1.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:78098
Gorski JA et al.,
"Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage."
J Neurosci 2002 Aug 1;22(15):6309-14
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All: |
93 reference(s)
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Analysis Tools
