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| Nomenclature |
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Symbol:
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F13a1tm1Gdi
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Name:
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coagulation factor XIII, A1 subunit;
targeted mutation 1, Gerhard Dickneite
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MGI ID: |
MGI:2684302 |
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Synonyms: |
FXIII-, FXIII-A- |
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Gene:
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F13a1
Location:
Chr13:36867178-37050244 bp, - strand
Genetic Position: Chr13,
14.44 cM
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Altered response to myocardial infraction in F13a1tm1Gdi/F13a1tm1Gdi mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:87293
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 2.5 kb fragment encompassing exon 7 was replaced with a neomycin selection cassette inserted by homologous recombination. Both coagulation factor XIII enzymatic activity and fibrin gamma-dimerization were undetected in plasma from homozygous mutant mice. (J:87293)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any F13a1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:87293
Lauer P et al.,
"Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit."
Thromb Haemost 2002 Dec;88(6):967-74
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All: |
10 reference(s)
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Analysis Tools
