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| Nomenclature |
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Symbol:
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St14tm1Bug
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Name:
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suppression of tumorigenicity 14 (colon carcinoma);
targeted mutation 1, Thomas H Bugge
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MGI ID: |
MGI:2683707 |
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Synonyms: |
Matriptase/MT-SP1 |
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Gene:
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St14
Location:
Chr9:31089402-31131853 bp, - strand
Genetic Position: Chr9,
16.61 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:87125
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Parent Cell Line:
| HM-1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd-Hprtb-m3
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment encompassing 350 bp of the putative intron 1 and the majority of the putative exon 2 was replaced with an hprt cassette inserted by homologous recombination. The deleted region encoded 19 of the 24 residues of the signal anchor required for membrane translocation. RT-PCR analysis identified mutant transcript in which the putative exon 1 spliced to the putative exon 3. This aberrant splice event results in a frameshift and ultimately a premature stop codon. (J:87125)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any St14 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:87125
List K et al.,
"Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis."
Oncogene 2002 May 23;21(23):3765-79
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All: |
11 reference(s)
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Analysis Tools
