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| Nomenclature |
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Symbol:
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Zap70m1Saka
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Name:
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zeta-chain (TCR) associated protein kinase;
mutation 1, Shimon Sakaguchi
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MGI ID: |
MGI:2683318 |
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Synonyms: |
SKG, ZAP-70skg, ZAP-70W163C |
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Gene:
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Zap70
Location:
Chr1:36761861-36782816 bp, + strand
Genetic Position: Chr1,
15.41 cM, cytoband A4-C1
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Single point mutation |
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Mutation details: A G-to-T transversion at nucleotide 489, resulting in a tryptophan to cysteine substitution at codon 163 (W163C), was identified on a BALB/c genetic background. (J:86607)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Zap70 Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:86607
Sakaguchi N et al.,
"Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice."
Nature 2003 Nov 27;426(6965):454-60
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All: |
9 reference(s)
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Analysis Tools
