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| Nomenclature |
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Symbol:
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Tg(PLADA)4118Rkmb
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Name:
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transgene insertion 4118, Michael R Blackburn
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MGI ID: |
MGI:2683027 |
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Transgene:
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Tg(PLADA)4118Rkmb
Location:
unknown
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Lung, bone and kidney abnormalities are observed in Adatm1Mw/Adatm1Mw Tg(PLADA)4118Rkmb/0 mice
Show the 2 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A construct was made that contained the endogenous polyadenylation sequence, intron 11, and ~2kb of of the 3' flanking region of the gene. The endogenous promoter was replaced with a promoter containing a 36-bp deletion in the 5'-untranslated region and 770-bp trophoblast regulatory element. This resulted in a construct that allowed expression in the placenta prenatally only, while the 36-bp deletion in the promoter allowed distinction of this transcript from that of native transcript. Enzymatic activity of the protein product was not detected in any of the tissues tested at postnatal day 17 in transgenic mice. (J:73418)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:73418
Blackburn MR et al.,
"Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency."
J Biol Chem 1998 Feb 27;273(9):5093-100
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All: |
6 reference(s)
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Analysis Tools
