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| Nomenclature |
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Symbol:
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Slc6a5tm1Betz
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Name:
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solute carrier family 6 (neurotransmitter transporter, glycine), member 5;
targeted mutation 1, Heinrich Betz
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MGI ID: |
MGI:2682554 |
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Synonyms: |
GlyT2-/- |
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Gene:
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Slc6a5
Location:
Chr7:49910299-49959493 bp, + strand
Genetic Position: Chr7,
31.71 cM, cytoband B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:86625
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 2.1 kb genomic fragment encompassing the exons encoding the fourth transmembrane domain was replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by RT-PCR or Western blot analyses of homozygous mutant brain stem tissue. The absence of protein was also verified in fractions obtained from mutant spinal cord extracts. (J:86625)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc6a5 Mutation:
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34 strains or lines available |
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| References |
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Original: |
J:86625
Gomeza J et al.,
"Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality."
Neuron 2003 Nov 13;40(4):797-806
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All: |
2 reference(s)
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Analysis Tools
