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| Nomenclature |
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Symbol:
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Slc6a9tm1Betz
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Name:
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solute carrier family 6 (neurotransmitter transporter, glycine), member 9;
targeted mutation 1, Heinrich Betz
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MGI ID: |
MGI:2682493 |
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Synonyms: |
GlyT1-/- |
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Gene:
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Slc6a9
Location:
Chr4:117834506-117875198 bp, + strand
Genetic Position: Chr4,
53.62 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:86624
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 3 was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of RNA obtained from homozygous mutant brain stem and spinal cord tissue. Similarly, Western blot analysis indicated an absence of protein in extracts from homozygous mutant brain stem and spinal cord tissue. (J:86624)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc6a9 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:86624
Gomeza J et al.,
"Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition."
Neuron 2003 Nov 13;40(4):785-96
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All: |
1 reference(s)
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Analysis Tools
