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| Nomenclature |
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Symbol:
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Prnptm1(PRNP)Tkit
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Name:
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prion protein;
targeted mutation 1, Tetsuyuki Kitamoto
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MGI ID: |
MGI:2681980 |
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Synonyms: |
Hu-Ki, Ki-ChM |
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Gene:
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Prnp
Location:
Chr2:131909928-131938429 bp, + strand
Genetic Position: Chr2,
64.07 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:33412
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: The majority of the endogenous mouse gene was replaced with mutant human PRNP sequence. The human sequence contained a nonsense mutation at codon 145. 3' mouse sequence remained downstream of the inserted human sequence. (J:33412, J:86603)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prnp Mutation:
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71 strains or lines available |
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| References |
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Original: |
J:33412
Kitamoto T et al.,
"Humanized prion protein knock-in by Cre-induced site-specific recombination in the mouse."
Biochem Biophys Res Commun 1996 May 24;222(3):742-7
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All: |
2 reference(s)
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Analysis Tools
