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| Nomenclature |
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Symbol:
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Ptentm2.1Ppp
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Name:
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phosphatase and tensin homolog;
targeted mutation 2.1, Pier Paolo Pandolfi
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MGI ID: |
MGI:2679886 |
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Synonyms: |
Ptenfl, PtenL, Ptenlox4-5, PtenloxP, Ptenlx |
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Gene:
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Pten
Location:
Chr19:32757497-32826160 bp, + strand
Genetic Position: Chr19,
28.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:86212
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Exons 4 and 5 were left flanked by single loxP sites after the floxed neo cassette was removed from intron 3 of Ptentm2Ppp via in vivo cre mediated recombination.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pten Mutation:
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36 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Astrocytoma (J:99385)
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| References |
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Original: |
J:86212
Trotman LC et al.,
"Pten Dose Dictates Cancer Progression in the Prostate."
PLoS Biol 2003 Dec;1(3):385-96
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All: |
30 reference(s)
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Analysis Tools
