|
|
| Nomenclature |
|
Symbol:
|
Kat6bGt(pKC199)1Pgr
|
|
Name:
|
K(lysine) acetyltransferase 6B;
gene trap 1, Peter Gruss
|
|
MGI ID: |
MGI:2679726 |
|
Synonyms: |
qkfgt, querkopfgt |
|
Gene:
|
Kat6b
Location:
Chr14:21499785-21672478 bp, + strand
Genetic Position: Chr14,
11.73 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:62161
|
|
Parent Cell Line:
| MPI-II (ES Cell) |
|
Strain of Origin:
|
129S2/SvPas
|
|
Mutation
description |
|
Allele
Type: | |
Gene trapped |
|
Mutation: | |
Insertion of gene trap vector |
| |
|
Mutation details: The insertion of a gene trap vector into a 5' untranslated exon resulted in a hypomorphic allele from which normal coding mRNA is produced at a level approximately 10% that of the wild-type. The insertion site corresponds with base 76 of the cDNA. (J:62161)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Kat6b Mutation:
|
43 strains or lines available |
|
|
Notes |
Phenotypic Similarity to Human Syndrome: Noonan syndrome in homozygous mice (J:178264)
|
| References |
|
Original: |
J:62161
Thomas T et al.,
"Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development."
Development 2000 Jun;127(12):2537-48
|
|
All: |
5 reference(s)
|
|
Analysis Tools
