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| Nomenclature |
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Symbol:
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Hif1atm1.1Stom
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Name:
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hypoxia inducible factor 1, alpha subunit;
targeted mutation 1.1, Shuhei Tomita
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MGI ID: |
MGI:2677899 |
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Synonyms: |
Hif-1alphadelta |
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Gene:
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Hif1a
Location:
Chr12:73901375-73947530 bp, + strand
Genetic Position: Chr12,
31.99 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85763
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 13, 14, and 15 were deleted by cre-mediated recombination of flanking loxP sites. The deleted region encoded the C-terminal transactivation domain that is involved in response to hypoxia, Cri2 recruitment, and efficient nuclear localization. Though a truncated protein consisting was detected, it was reported to be non-functional. (J:85763)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hif1a Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:85763
Tomita S et al.,
"Defective brain development in mice lacking the Hif-1alpha gene in neural cells."
Mol Cell Biol 2003 Oct;23(19):6739-49
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All: |
2 reference(s)
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Analysis Tools
