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| Nomenclature |
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Symbol:
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Sall1tm1Mrau
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Name:
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sal-like 1 (Drosophila);
targeted mutation 1, Michael Rauchman
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MGI ID: |
MGI:2677452 |
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Synonyms: |
sall1delta, Sall1-deltaZn, Sall1-deltaZn2-10 |
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Gene:
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Sall1
Location:
Chr8:89027248-89044162 bp, - strand
Genetic Position: Chr8,
43.51 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85458
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A dominant-negative allele, recapitulating the human SALL1 1277-1278delGA mutation, was generated by inserting a stop codon and a floxed neo cassette into the exon 2. The deleted region corresponded with nt 1300-3443 of the cDNA. A truncated protein was detected by Western blot analyis of homozygous mutant embryonic tissue using an N-terminal antibody. (J:85458)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sall1 Mutation:
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33 strains or lines available |
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| References |
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Original: |
J:85458
Kiefer SM et al.,
"Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects."
Hum Mol Genet 2003 Sep 1;12(17):2221-7
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All: |
3 reference(s)
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Analysis Tools
