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| Nomenclature |
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Symbol:
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Glra1tm1Rah
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Name:
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glycine receptor, alpha 1 subunit;
targeted mutation 1, R Adron Harris
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MGI ID: |
MGI:2676917 |
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Gene:
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Glra1
Location:
Chr11:55514238-55608198 bp, - strand
Genetic Position: Chr11,
33.12 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85341
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Exon 7 was modified so that the codon for serine at amino acid position 267 (AGC) has been changed to one that codes for glutamine (CAG). At the same time, a neomycine resistance gene flanked by FLP recombinase target sites. F1 heterozygotes were mated to FLP general deleter mice to remove the neo marker gene. (J:85341)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Glra1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:85341
Findlay GS et al.,
"Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant."
J Neurosci 2003 Sep 3;23(22):8051-9
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All: |
1 reference(s)
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Analysis Tools
