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| Nomenclature |
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Symbol:
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Pkd2tm1Dwo
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Name:
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polycystic kidney disease 2;
targeted mutation 1, Bernd Dworniczak
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MGI ID: |
MGI:2676373 |
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Synonyms: |
Pkd2-/-lacZ+/+, Pkd2tm1Blum |
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Gene:
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Pkd2
Location:
Chr5:104459450-104505819 bp, + strand
Genetic Position: Chr5,
50.68 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77401
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 and a portion of intron 1 were replaced with a cassette containing lacZ and PGK-neo. Transcript was undetected in homozygous mutant embryos at E16.5 by Northern blot analysis. (J:77401)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:77401
Pennekamp P et al.,
"The ion channel polycystin-2 is required for left-right axis determination in mice."
Curr Biol 2002 Jun 4;12(11):938-43
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All: |
2 reference(s)
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Analysis Tools
