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| Nomenclature |
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Symbol:
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Crb1rd8
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Name:
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crumbs homolog 1 (Drosophila);
retinal degeneration 8
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MGI ID: |
MGI:2676366 |
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Synonyms: |
nmf144 |
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Gene:
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Crb1
Location:
Chr1:139197056-139377100 bp, - strand
Genetic Position: Chr1,
60.87 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Intragenic deletion |
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Mutation details: The mutation in the rd8 mouse has been identified as a single base deletion in the Crb1 gene. This deletion causes a frame shift and a premature stop codon that truncates the transmembrane and cytoplasmic domain of the protein. (J:85459)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:85459
Mehalow AK et al.,
"CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina."
Hum Mol Genet 2003 Sep 1;12(17):2179-89
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All: |
10 reference(s)
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Analysis Tools
