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| Nomenclature |
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Symbol:
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Tg(Tyr-HRAS)60Lc
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Name:
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transgene insertion 60, Lynda Chin
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MGI ID: |
MGI:2676096 |
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Synonyms: |
Tyr-RAS |
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Transgene:
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Tg(Tyr-HRAS)60Lc
Location:
unknown
Genetic Position: ChrY,
Syntenic
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA/J)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mutant human H-Ras (G12V) has been placed under the control of the tyrosinase promoter and distal enhancer followed by the SV40 splice and polyadenylation sequences. Transgene copy number is low and integration was on the Y chromosome.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Transgenic animals were produced from two founders, TR39 and TR60, that possessed low transgene copy number and expression level. In TR60, the transgene had inserted into the Y chromosome.
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| References |
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Original: |
J:44088
Chin L et al.,
"Cooperative effects of INK4a and ras in melanoma susceptibility in vivo."
Genes Dev 1997 Nov 1;11(21):2822-34
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All: |
13 reference(s)
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Analysis Tools
