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| Nomenclature |
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Symbol:
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Gas6tm1Pec
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Name:
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growth arrest specific 6;
targeted mutation 1, Peter Carmeliet
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MGI ID: |
MGI:2675495 |
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Synonyms: |
Gas6- |
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Gene:
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Gas6
Location:
Chr8:13465374-13494535 bp, - strand
Genetic Position: Chr8,
6.06 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77462
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Sequences encoding the transcription start site, the start codon, the signal peptide, and the Gla module which is required for binding of the endogenous protein to phospholipid membranes were deleted. Normal transcript was undetected by Northern blot analysis of MEFs derived from homozygous mutant mice, while normal protein was shown to be absent from homozygous mutant kidney extracts by Western blot analysis using an antibody directed against the C-terminal. (J:77462)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gas6 Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:77462
Angelillo-Scherrer A et al.,
"Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis."
Nat Med 2001 Feb;7(2):215-21
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All: |
12 reference(s)
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Analysis Tools
