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| Nomenclature |
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Symbol:
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Men1tm1.2Zqw
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Name:
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multiple endocrine neoplasia 1;
targeted mutation 1, Zhao-Qi Wang
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MGI ID: |
MGI:2675250 |
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Synonyms: |
Men1F |
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Gene:
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Men1
Location:
Chr19:6334979-6340891 bp, + strand
Genetic Position: Chr19,
4.45 cM, cytoband A
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85133
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: Single loxP sites were left flanking exon 3 after floxed sequence encompassing the neomycin resistance gene and the thymidine kinase gene was removed from Men1tm1Zqw via expression of cre recombinase in the germline. (J:85133)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Men1 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:85133
Bertolino P et al.,
"Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice."
Cancer Res 2003 Aug 15;63(16):4836-41
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All: |
3 reference(s)
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Analysis Tools
