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| Nomenclature |
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Symbol:
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Rasgrp1lag
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Name:
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RAS guanyl releasing protein 1;
lymphoproliferation autoimmunity glomerulonephritis
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MGI ID: |
MGI:2675033 |
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Gene:
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Rasgrp1
Location:
Chr2:117279993-117343001 bp, - strand
Genetic Position: Chr2,
59.19 cM
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Spontaneous |
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Mutation: | |
Other |
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Mutation details: The spontaneous mutation that arose on a 129 background results in the generation of 2 aberrantly spliced transcripts that lack exon 4 and are putatively translated into nonfunctional polypeptides. The mutation suppresses the use of the splice donor site located at the beginning of intron 3 and enables the utilization of cryptic splice sites located in intron 3 resulting in the splicing of intron 3 to exon 5. (J:85189)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rasgrp1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:85189
Layer K et al.,
"Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1."
Immunity 2003 Aug;19(2):243-55
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All: |
1 reference(s)
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Analysis Tools
