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| Nomenclature |
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Symbol:
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Tlr2tm1Kir
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Name:
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toll-like receptor 2;
targeted mutation 1, Carsten J Kirschning
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MGI ID: |
MGI:2674036 |
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Synonyms: |
Ly105, TLR2- |
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Gene:
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Tlr2
Location:
Chr3:83836272-83841608 bp, - strand
Genetic Position: Chr3,
37.4 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85323
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encoding the extracellular domain and a portion of the transmembrane domain was replaced with a neo cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of peritoneal macrophages obtained from homozygous mutant mice. (J:85323, J:130011)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:85323
Wooten RM et al.,
"Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi."
J Immunol 2002 Jan 1;168(1):348-55
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All: |
168 reference(s)
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Analysis Tools
