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| Nomenclature |
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Symbol:
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Tg(Thy1-MAPT)183Gotz
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Name:
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transgene insertion 183, Jurgen Gotz
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MGI ID: |
MGI:2672839 |
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Synonyms: |
P301L tau, pR5 |
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Transgene:
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Tg(Thy1-MAPT)183Gotz
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Sequence encoding the longest human MAPT brain isoform (tau40), consisting of exons 2 and 3 as well as four microtubule-binding repeats, was adjoined to the murine Thy1 promoter. The human MAPT sequence included the P301L point mutation, which is linked to human frontotemporal dementia with parkinsonism. Soluble levels of transgenic protein in the brain were approximately 70% of the endogenous level. Expression levels of transgenic protein were high in the hippocampus, fornix fimbriae, amygdala, spinal cord, and cortex, weaker in brain stem and striatum, and not detectable in the olfactory bulb and cerebellum. (J:66831)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:66831
Gotz J et al.,
"Tau filament formation in transgenic mice expressing P301L tau."
J Biol Chem 2001 Jan 5;276(1):529-34
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All: |
14 reference(s)
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Analysis Tools
