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| Nomenclature |
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Symbol:
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Kmt2atm2(MLLT3)Thr
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Name:
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lysine (K)-specific methyltransferase 2A;
targeted mutation 2, Terence H Rabbitts
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MGI ID: |
MGI:2671905 |
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Synonyms: |
Mll1tm2Thr, Mllaf9, Mll-AF9+ |
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Gene:
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Kmt2a
Location:
Chr9:44803355-44881296 bp, - strand
Genetic Position: Chr9,
24.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75959
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Sequence encoding a 3' portion of human MLLT3 extending from nucleotide 1634 to the translation terminus replaced a 3' portion of murine Mll exon 8. A downstream neo cassette was also included in the targeting vector for selection. The resultant fusion product putatively recapitulates the MLL/MLLT3 protein produced in patients with the acute myeloid leukamia (AML) associated transloaction T(9;11)(p22;q23). (J:75959)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:75959
Corral J et al.,
"An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes."
Cell 1996 Jun 14;85(6):853-61
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All: |
11 reference(s)
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Analysis Tools
