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| Nomenclature |
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Symbol:
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Runx1tm1Buch
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Name:
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runt related transcription factor 1;
targeted mutation 1, Frank Buchholz
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MGI ID: |
MGI:2671464 |
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Synonyms: |
AMLX |
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Gene:
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Runx1
Location:
Chr16:92601467-92826066 bp, - strand
Genetic Position: Chr16,
53.7 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:68499
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Other |
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Mutation details: A floxed neo cassette was inserted into intron 5, 1496 bp downstream of exon 5. This allele was initially generated for use in the engineering of T(4;16), a reciporical translocation that replicates the human acute myeloid leukemia (AML) associated translocation, T(8;21). (J:68499)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Runx1 Mutation:
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10 strains or lines available |
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| References |
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Original: |
J:68499
Buchholz F et al.,
"Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse."
EMBO Rep 2000 Aug;1(2):133-9
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All: |
1 reference(s)
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Analysis Tools
