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| Nomenclature |
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Symbol:
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Rdxtm1Sts
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Name:
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radixin;
targeted mutation 1, Shoichiro Tsukita
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MGI ID: |
MGI:2671151 |
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Synonyms: |
Rdx- |
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Gene:
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Rdx
Location:
Chr9:52047150-52088737 bp, + strand
Genetic Position: Chr9,
28.62 cM
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Stereocilia abnormalities on Rdxtm1Sts/Rdxtm1Sts cochlear hair cells of adult and newborn mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:77485
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment including exon 3 was replaced with a cassette containing a spice acceptor sie, an internal ribosomal entry site followed by a lacZ gene, and a neomycin selection gene. Western blot analysis of kidney and liver proteins derived from homozygous mice demonstrated that no detectable protein was made from this allele. (J:77485)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rdx Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:77485
Kikuchi S et al.,
"Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes."
Nat Genet 2002 Jul;31(3):320-5
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All: |
3 reference(s)
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Analysis Tools
