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| Nomenclature |
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Symbol:
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Festm1Pag
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Name:
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feline sarcoma oncogene;
targeted mutation 1, Peter A Greer
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MGI ID: |
MGI:2670783 |
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Synonyms: |
FesKR, fpsK588R, fpsKR |
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Gene:
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Fes
Location:
Chr7:80377758-80387946 bp, - strand
Genetic Position: Chr7,
45.65 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84535
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: A dinucleotide substitution was introduced at codon 588 (exon 14), converting the lysine codon to an arginine codon. While protein was detected at wild-type levels in homozygous mutant mice, the absence of lysine 588, a conserved residue of the kinase subdomain II, resulted in an ablation of catalytic activity. The targeting construct also included neo and tk selection genes in the 3' untranslated region. (J:84535)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Fes Mutation:
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1 strain or line available |
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| References |
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Original: |
J:84535
Senis Y et al.,
"Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis."
Mol Cell Biol 1999 Nov;19(11):7436-46
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All: |
5 reference(s)
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Analysis Tools
