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| Nomenclature |
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Symbol:
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Mapttm1(EGFP)Klt
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Name:
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microtubule-associated protein tau;
targeted mutation 1, Kerry Lee Tucker
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MGI ID: |
MGI:2670768 |
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Synonyms: |
Mapttm1(GFP)Klt, tauGFP, tau ko |
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Gene:
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Mapt
Location:
Chr11:104231390-104332090 bp, + strand
Genetic Position: Chr11,
67.79 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66561
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: Exon 1 was disrupted by the insertion of a cassette encoding EGFP and neo. Fusion protein including GFP was detected by Western blot analysis of homozygous mutant brain lysates. Fluorescent illumination indicated that expression of the reporter gene was similar to that of the endogenous gene. (J:66561)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:66561
Tucker KL et al.,
"Neurotrophins are required for nerve growth during development."
Nat Neurosci 2001 Jan;4(1):29-37
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All: |
21 reference(s)
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Analysis Tools
