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| Nomenclature |
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Symbol:
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Ptstm1Ich
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Name:
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6-pyruvoyl-tetrahydropterin synthase;
targeted mutation 1, Hiroshi Ichinose
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MGI ID: |
MGI:2669870 |
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Gene:
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Pts
Location:
Chr9:50521618-50528641 bp, - strand
Genetic Position: Chr9,
27.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84764
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was replaced with a PGK-neo cassette inserted by homologous recombination. Normal transcript was undetected by Northern blot analysis of homozygous mutant liver and brain tissue. (J:84764)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:84764
Sumi-Ichinose C et al.,
"Catecholamines and serotonin are differently regulated by tetrahydrobiopterin. A study from 6-pyruvoyltetrahydropterin synthase knockout mice."
J Biol Chem 2001 Nov 2;276(44):41150-60
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All: |
4 reference(s)
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Analysis Tools
