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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm1(cre/ERT)Nat
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 1, Jeremy Nathans
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MGI ID: |
MGI:2669525 |
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Synonyms: |
CreERT1, Gt(ROSA)26Sortm1(cre/Esr1)Nat, R26CreER, R26ERCre, R26RNatCre |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84747
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A cDNA fragment encoding a fusion protein comprised of cre recombinase and the ligand binding domain of Esr1 was inserted at the endogenous locus via homologous recombination. The initiator methionine was placed in an optimal translational context, allowing for near ubiquitous expression via the endogenous promoter. Activation of cre recombinase activity is dependent on the administration of 4-HO-tamoxifen. (J:84747)
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Inheritance: | |
Dominant |
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:84747
Badea TC et al.,
"A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse."
J Neurosci 2003 Mar 15;23(6):2314-22
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All: |
53 reference(s)
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Analysis Tools
