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| Nomenclature |
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Symbol:
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Trpv4tm1Msz
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Name:
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transient receptor potential cation channel, subfamily V, member 4;
targeted mutation 1, Makoto Suzuki
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MGI ID: |
MGI:2667379 |
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Synonyms: |
Trpv4-, TRPV4KO |
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Gene:
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Trpv4
Location:
Chr5:114622152-114658421 bp, - strand
Genetic Position: Chr5,
55.99 cM, cytoband F
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84093
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A neomycin resistance gene was inserted into exon 4 which encodes the ankyrin-repeat domain. Transcripts were undetectable by RT-PCR and Northern blot in trigeminal root and dorsal root ganglia of homozygous animals. Immunohistochemical staining of the dorsal root ganglion confirmed the success of gene disruption. (J:84093)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:84093
Suzuki M et al.,
"Impaired pressure sensation in mice lacking TRPV4."
J Biol Chem 2003 Jun 20;278(25):22664-8
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All: |
16 reference(s)
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Analysis Tools
