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| Nomenclature |
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Symbol:
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Ywhaetm1Awb
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Name:
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tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide;
targeted mutation 1, Anthony Wynshaw-Boris
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MGI ID: |
MGI:2667341 |
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Synonyms: |
14-3-3epsilon-, Ywhae- |
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Gene:
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Ywhae
Location:
Chr11:75732869-75765845 bp, + strand
Genetic Position: Chr11,
45.92 cM, cytoband B2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84075
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2 and 3 were partially replaced by a neomycin resistance gene and a loxP site. Immunoblot analysis indicated the complete absence of gene product in homozygotes and a reduction by half in heterozygotes. (J:84075)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:84075
Toyo-oka K et al.,
"14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome."
Nat Genet 2003 Jul;34(3):274-85
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All: |
8 reference(s)
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Analysis Tools
