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| Nomenclature |
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Symbol:
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Slc27a4tm1Wsr
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Name:
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solute carrier family 27 (fatty acid transporter), member 4;
targeted mutation 1, Wolfgang Stremmel
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MGI ID: |
MGI:2667328 |
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Synonyms: |
Fatp4-, Fatp4flox, Fatp4-K |
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Gene:
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Slc27a4
Location:
Chr2:29802634-29817522 bp, + strand
Genetic Position: Chr2,
20.64 cM, cytoband B
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Abnormal appearance of Slc27a4tm1Wsr/Slc27a4tm1Wsr mice, with facial dysmorphia, skin abnormalities and a rigid torso
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84096
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A 7172 bp insert containing a splice acceptor, IRES, lacZ reporter gene and a neomycin resistance gene, all flanked by two FLP recombinase target sites was placed in intron 2 at the same time that loxP sites were inserted on either side of exon 3. Northern blot analysis established the absence of mRNA transcripts from the targeted gene and Western blots demonstrated the absence of protein products. (J:84096)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc27a4 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:84096
Herrmann T et al.,
"Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy."
J Cell Biol 2003 Jun 23;161(6):1105-15
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All: |
4 reference(s)
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Analysis Tools
