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| Nomenclature |
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Symbol:
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Ahrb-1
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Name:
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aryl-hydrocarbon receptor;
b-1 variant
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MGI ID: |
MGI:2667308 |
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Synonyms: |
Ah, Ahb, Ahb-1, Ahhi, Ahrb, In |
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Gene:
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Ahr
Location:
Chr12:35497974-35535038 bp, - strand
Genetic Position: Chr12,
15.78 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Not Applicable |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: This allele encodes a high affinity, relatively heat stabile, 95 kDa receptor. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). A second C to T transition changes a proline codon in the DBA/2J allele to leucine codon in the C57BL/6J allele, and would likely change secondary structure of the peptide and thus ligand affinity.
(J:477, J:15153, J:17460)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460).
Strain of origin - this allele was found in C57BL/6, C58/J, C57BR, MA/My strains
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| References |
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Original: |
J:26440
Schmid FA et al.,
"Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice."
Cancer Res 1967 Mar;27(3):558-62
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All: |
44 reference(s)
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Analysis Tools
